MABF384
Anti-CD127 (IL-7Ra) Antibody (mouse), clone A7R34
clone A7R34, 0.5 mg/mL, from rat
Synonym(s):
Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
A7R34, monoclonal
Application:
FACS, IF, IHC, IP
Citations:
1
biological source
rat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
A7R34, monoclonal
species reactivity
mouse
concentration
0.5 mg/mL
technique(s)
flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable
isotype
IgG2aκ
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Il7R(16197)
General description
The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
Application
This Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), clone A7R34, Cat. No. MABF384 is validated for use in IP, IHC, Immunofluorescence and Flow Cytometry for the detection of CD127 (IL-7Ra).
Physical form
Format: Purified
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Gabrielle L Goldberg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 6014-6024 (2010-05-21)
Cytotoxic antineoplastic therapy is used to treat malignant disease but results in long-term immunosuppression in postpubertal and adult individuals, leading to increased incidence and severity of opportunistic infections. We have previously shown that sex steroid ablation (SSA) reverses immunodeficiencies associated
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABF384 | 04053252959608 |