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PCC300C45G

Pellicon® Capsule with Ultracel® Membrane

C Screen, 4.5 m² manifold AseptiQuik® G connectors

Synonym(s):

Pellicon® Capsule with Ultracel® Membrane

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About This Item

UNSPSC Code:
23151806
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Product Name

Pellicon® Capsule 4.5 m2 Ultracel® 300 kDa C Screen, Feed: AseptiQuik® G Connector Retentate: AseptiQuik® G Connector Permeate: AseptiQuik® G Connector

Quality Level

400

material

EPDM rubber seal, PPO/PS blend (core
core), PPO/PS blend housing, TPE seal, composite regenerated cellulose (CRC) membrane, epoxy adhesive, polyester screen, polypropylene seal, polyurethane adhesive

sterility

sterile; γ-irradiated

product line

Pellicon®

feature

holdup volume 1667 mL (in feed channel), holdup volume 2541 mL (in permeate channel)

packaging

package of 1

parameter

max. inlet pressure at 60 psi (4.1 bar) and 4-30 °C, max. transmembrane pressure at 45 psi (3.1 bar) and 4-30 °C, 4-6 L/min-m2 flow rate

technique(s)

ultrafiltration: suitable

filtration area

4.5 m2

screen size

, Type C screen (coarse screen)

size

44.2 cm (17.4 in.) , Height, 54.6 cm (21.5 in.) , Length

width

45.4 cm (17.9 in.) , 454 mm

impurities

≤5 ppm Meets TOC (in retentate effluent, after a WFI flush of 20 L/m²)

matrix

Ultracel®

pore size

300 kDa

pH range

2-13

storage temp.

15-25°C

General description

The Pellicon® Capsule is the first of its kind -- a true single-use TFF device that comes ready to process in minutes. Self-contained, it employs an easy-to-use, holderless format and is supplied sterilized by irradiation.
Feed: AseptiQuik® G Connector
Permeate: AseptiQuik® G Connector
Retentate: AseptiQuik® G Connector
Permeate: AseptiQuik® G Connector

Application

Viral Gene Therapies, Vaccines, Concentration, Diafiltration, Buffer exchange, Protein purification, mRNA

Features and Benefits

  • Plug ′n play, holderless design - easy to install, safe to remove
  • Gamma Sterilized and preseravtive-free - ready to process in minutes
  • True single-use, self-contained capusle - fast, safe, and flexible batch turnaround
  • Proven Ultracel® membrane and C screen - high recovery, superior mass transfer, solvent resistance
  • Pellicon® TFF proven performance - true linear scalability within Pellicon® TFF families

Packaging

The manifold assembly is inserted into a polyethylene foam frame and then double bagged and vacuum sealed. The double-bagged assembly is placed within a second foam frame and individually boxed (qty 1 per box). Packaged assemblies are palletized.

Other Notes

The Emprove® Program complements the product portfolio through

  • Comprehensive documentation to support qualification, risk assessment and process optimization needs.
  • Consolidation of product specific testing, quality and regulatory information to simplify compliance requirements.
  • Convenient 24/7 access to up-to-date product information.

Legal Information

AseptiQuik is a registered trademark of Colder Products Company
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
Pellicon is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTRACEL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Articles

Scalable Tangential Flow Filtration (TFF) for Downstream Processing of Viral Vectors for Gene Therapy and Vaccine Production

Our overview of scalable tangential flow filtration for viral vector production will provide key considerations for developing and optimizing your downstream process.