03440
N-Ethyldiisopropylamine
≥98.0%, liquid
Synonym(s):
N,N-Diisopropylethylamine, Hünigs base
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About This Item
Linear Formula:
CH3CH2N[CH(CH3)2]2
CAS Number:
Molecular Weight:
129.24
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
230-392-0
MDL number:
Beilstein/REAXYS Number:
605301
Assay:
≥98.0%
Form:
liquid
Product Name
N-Ethyldiisopropylamine, ≥98.0%
Quality Level
assay
≥98.0%
form
liquid
impurities
≤0.5% water
refractive index
n20/D 1.414
bp
126-128 °C (lit.)
density
0.755 g/mL at 20 °C, 0.757 g/mL at 25 °C (lit.)
functional group
amine
SMILES string
CCN(C(C)C)C(C)C
InChI
1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChI key
JGFZNNIVVJXRND-UHFFFAOYSA-N
General description
N,N-Diisopropylethylamine (DIPEA), also known as Hunig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed in substitution reactions, alkylations, and amide couplings, etc. DIPEA is also used as a base in the Pd catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.
Application
- Catalytic activity in dioxygen reduction: A study utilized Mn complexes with pendent proton donor relays and added base, including N-Ethyldiisopropylamine, to control product selectivity during dioxygen reduction, providing insights into catalytic mechanisms and potential industrial applications (Cook et al., 2024).
- Three-dimensional imaging in medical applications: N-Ethyldiisopropylamine was mentioned in the context of its role in improving the resolution of three-dimensional imaging techniques based on computed tomography angiography (CTA), crucial for preoperative perforator selection in reconstructive surgery (Su et al., 2024).
- Synthesis of Spirocyclopropane-Containing Compounds: Research demonstrated the application of N-Ethyldiisopropylamine in the synthesis of spirocyclopropane-containing 4H-pyrazolo[1,5-a]indoles through alkylative dearomatization and intramolecular N-imination, highlighting its utility in complex organic synthesis (Huang et al., 2023).
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Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.1 °F
flash_point_c
9.5 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Palladium-catalysed cross-coupling reactions in supercritical carbon dioxide
Early TR, et al.
Chemical Communications (Cambridge, England), 73(19), 1966-1967 (2001)
An easy and fast ultrasonic selective S-alkylation of hetaryl thiols at room temperature
Deligeorgiev T, et al.
Ultrasonics Sonochemistry, 17(5), 783-788 (2010)
Probing the structural properties of DNA/RNA grooves with sterically restricted phosphonium dyes: screening of dye cytotoxicity and uptake
Crnolatac I, et al.
ChemMedChem, 8(7), 1093-1103 (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 241733-100G | 04061825411040 |
| 1017380250 | 04022536024271 |
| 1017381000 | 04022536024288 |
| 03440-1L | 04061838618603 |
| 03440-4X25ML | 04061837357619 |
| 03440-250ML | 04061838618610 |
| 03440-25ML | 04061837357602 |
| 03440-50ML | 04061838618658 |