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07964

Methoxypolyethylene glycol amine

Name: Methoxypolyethylene glycol amine
Brand: SIAL

750 MW

Synonym(s):

mPEG-NH₂, O-(2-Aminoethyl)-O′-methylpolyethylene glycol, Aminopolyethylene glycol monomethyl ether, Methoxypolyoxyethylene amine

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About This Item

Linear Formula:

H₂NCH₂CH₂(OCH₂CH₂)_nOCH₃

CAS Number:

80506-64-5

NACRES:

NA.22

UNSPSC Code:

12162002

MDL number:

MFCD00131599

Form:

solid

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Properties

Quality Level

100

form

solid

color

white to yellow

InChI

1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3

InChI key

ASUDFOJKTJLAIK-UHFFFAOYSA-N

Description

Application

Methoxypolyethylene glycol amine can:

Form dendritic micelles to enhance the solubility of hydrophobic compounds.
Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.
Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.

Other Notes

Oligomer used to prepare PEG-ylated conjugates having the advantage of reduced immunogenicity and increased serum half life

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Fouling Resistant PEG Based Grafted Polymer Coatings

Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.

Effect of polyethylene glycol on gene delivery of polyethylenimine.

Sung SJ, et al.

Biological & Pharmaceutical Bulletin, 26(4), 492-500 (2003)

Preparation of micelle-forming polymer-drug conjugates.

M Yokoyama et al.

Bioconjugate chemistry, 3(4), 295-301 (1992-07-01)

Adriamycin, a hydrophobic anticancer drug, was conjugated with poly(ethylene oxide)-poly(aspartic acid) block copolymers composed of various lengths of each block copolymer segment ranging from 1000 to 12,000 in molecular weight and from 10 to 80 units, respectively. Conjugation was achieved

Polyethylene Glycol Conjugates of Methotrexate Varying in Their Molecular Weight from MW 750 to MW 40000: Synthesis, Characterization, and Structure- Activity Relationships in Vitro and in Vivo.

Riebeseel K, et al.

Bioconjugate Chemistry, 13(4), 773-785 (2002)

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Global Trade Item Number

SKU	GTIN
V900708-500G	04061832114002
246352-100G	04061825858845
246352-500G	04061838347923
V900708-100G	04061832113999
07964-1G	04061826661352
07964-250MG	04061833489727