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Sigma-Aldrich

Sodium dodecyl sulfate

ACS reagent, ≥99.0%

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Synonym(s):
Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate
Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
151-21-3
Molecular Weight:
288.38
Beilstein:
3599286
EC Number:
205-788-1
MDL number:
MFCD00036175
eCl@ss:
39093306
PubChem Substance ID:
24867284
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

description

anionic
 62

Assay

≥99.0%

form

solid

mol wt

288.38 g/mol

impurities

≤0.06 meq/g Titr. Base
≥96.0% fatty alcohols
<4.0% unsulfated alcohols

loss

≤1.0% loss on drying

mp

204-207 °C (lit.)

solubility

H2O: soluble 1 gm in 10 ml (opalescent solution)

cation traces

heavy metals (as Pb): ≤0.002%

λ

3 %H2O reference

UV absorption

λ: 220-350 nm Amax: ≤0.1

HLB

40

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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Application

Sodium dodecyl sulfate was used as a test compound for studying that whether Bacillus amyloliquefaciens KPS46 can induce priming, signaling, protein production as well as systemic protection in soybean (Glycine max L.) against several diseases.
Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS) is an anionic detergent that can form complexes with protein through hydrophobic interactions. Studies have reported that the hydrodynamic functions of protein-SDS complexes are governed by the length of their polypeptide chains. Thus, SDS-based electrophoretic techniques can separate protein molecules based on their molecular weights. Additionally, SDS can solubilize cell membranes and can extract membrane-bound proteins.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 2

Flash Point(F)

338.0 °F

Flash Point(C)

170 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Priming, signaling, and protein production associated with induced resistance by Bacillus amyloliquefaciens KPS46.
Natthiya Buensanteai
World Journal of Microbiology & Biotechnology, 25 (2009)
The gross conformation of protein-sodium dodecyl sulfate complexes.
J A Reynolds et al.
The Journal of biological chemistry, 245(19), 5161-5165 (1970-10-10)
K Fujimoto
Journal of cell science, 108 ( Pt 11), 3443-3449 (1995-11-01)
We propose a new electron microscopic method, the sodium dodecylsulphate (SDS)-digested freeze-fracture replica labeling technique, to study the two-dimensional distribution of integral membrane proteins in cellular membranes. Unfixed tissue slices were frozen with liquid helium, freeze-fractured, and replicated in a
Shane Stegeman et al.
Cancer discovery, 5(4), 368-379 (2015-02-19)
Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis
Susanne Kohl et al.
Nature genetics, 47(7), 757-765 (2015-06-02)
Achromatopsia (ACHM) is an autosomal recessive disorder characterized by color blindness, photophobia, nystagmus and severely reduced visual acuity. Using homozygosity mapping and whole-exome and candidate gene sequencing, we identified ten families carrying six homozygous and two compound-heterozygous mutations in the
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