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65943

N-Methyl-bis(trifluoroacetamide)

derivatization grade (GC derivatization), LiChropur™, ≥99.0% (GC)

Synonym(s):

MBTFA

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About This Item

Linear Formula:
CF3CON(CH3)COCF3
CAS Number:
685-27-8
Molecular Weight:
223.07
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
329760134
EC Number:
211-680-5
Beilstein/REAXYS Number:
1878402
MDL number:
MFCD00000412
Assay:
≥99.0% (GC)
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grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥99.0% (GC)

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.346

bp

121-122 °C (lit.)

density

1.547 g/mL at 25 °C

SMILES string

CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F

InChI

1S/C5H3F6NO2/c1-12(2(13)4(6,7)8)3(14)5(9,10)11/h1H3

InChI key

AWGBWLXGUPTXHF-UHFFFAOYSA-N

General description

N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.

Application

N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B6 vitamers), and thiols.
Reagent for introducing trifluoroacetyl group.

Other Notes

Reagent for trifluoroacetylations under mild conditions
Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

FlameCorrosion
GHS02,GHS05

signalword

Danger

hcodes

H226,H314

Hazard Classifications

Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCBX8730
BCBQ6576V

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K. Blau et al.
Handbook of Derivatives for Chromatography, 131-131 (1977)
[Acylation with bis(acylamides). N-methyl-bis(trifluoroacetamide) and bis(trifluoroacetamide), two new reagents for trifluoroacetylation].
M Donike
Journal of chromatography, 78(2), 273-279 (1973-04-25)
N Pizarro et al.
Journal of pharmaceutical and biomedical analysis, 21(4), 739-747 (2000-03-04)
We developed a fast and sensitive method for identification and quantification of plasma concentrations of amphetamine using gas chromatography with mass spectrometry detection (GC-MS). Amphetamine-d8 served as internal standard. The method involves a single extraction procedure and an easy treatment
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Global Trade Item Number

SKUGTIN
65943-5ML04061832733791
65943-25ML04061837811173