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A5131

Sigma-Aldrich

L-Arginine monohydrochloride

reagent grade, ≥98% (HPLC), powder

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Synonym(s):
(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride
Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

grade

reagent grade

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white

mp

>235 °C

solubility

H2O: 50 mg/mL

application(s)

cell analysis

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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Application

L-Arginine monohydrochloride has been used to study the effects of amino acids in promoting food consumption in Drosophila melanogaster. It has also been used to develop a non-invasive chronic pancreatitis model of rat.

Biochem/physiol Actions

L-Arginine is a semi-essential amino acid. This dibasic amino acid acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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  5. Are solutions of Product No. A5131 (L-Arginine monohydrochloride) autoclavable?

    Arginine is routinely autoclaved as a component of microbial media with no adverse effects; therefore solutions of A5131 L-Arginine monohydrochloride may be autoclaved.

  6. What is the method of preparation process for the A5131 L-Arginine monohydrochloride?

    No animal proteins or products are used in the fermentation process or purification of the L-Arginine.

  7. What are the solubility properties of L-Arginine monohydrochloride (Product No. A5131)?

    L-Arginine monohydrochloride is soluble in water at a concentration of 1M (210 mg/mL).

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Severe Chronic Pancreatitis due to Recurrent Acute Injury: Non-Invasive Chronic Pancreatitis Model of Rat
Surendra Sharma
Pancreas (2016)
Yang Liu et al.
Biochemical and biophysical research communications, 525(3), 620-625 (2020-03-03)
The circadian clock, a biochemical oscillator, plays a fundamental role in health and diseases. Ferroptosis, a type of regulated cell death driven by oxidative stress, is a prominent feature in iron-induced tissue injury. However, whether an impaired circadian clock contributes
An internal sensor detects dietary amino acids and promotes food consumption in Drosophila
Zhe Yang
Nature (2017)
Yangyang Hu et al.
Journal of cellular physiology, 234(12), 21988-21998 (2019-05-07)
The severity of acute pancreatitis (AP) is greatly attributed to the pancreatic acinar cell (PAC) death response. It has been established that the apoptosis-inducing therapy can protect against experimental pancreatitis and have great clinical therapeutic potential. However, current pharmacologic agents
J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health (2012)

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