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BP464

Prednisolone

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
50-24-8
Molecular Weight:
360.44
EC Number:
200-021-7
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
1354103
MDL number:
MFCD00003649
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grade

pharmaceutical primary standard

API family

prednisolone

form

crystalline

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

240 °C (dec.) (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Prednisolone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Estriol Cream
  • Prednisolone Sodium Phosphate Ear Drops
  • Prednisolone Sodium Phosphate Eye Drops
  • Prednisolone Tablets
  • Prednisolone Soluble Tablets
  • Prednisolone Enema
  • Prednisolone Sodium Phosphate Oral Solution
  • Prednisolone Gastro-resistant Tablets

    • Other Notes

    Sales restrictions may apply.

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    Hazard Classifications

    Repr. 1B

    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    hcodes

    H360FD

    Storage Class

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 2

    Regulatory Information

    监管及禁止进口产品

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    Carolien Out et al.
    Journal of hepatology, 61(2), 351-357 (2014-04-01)
    Glucocorticoids, produced by the adrenal gland under control of the hypothalamic-pituitary-adrenal axis, exert their metabolic actions largely via activation of the glucocorticoid receptor (GR). Synthetic glucocorticoids are widely used as anti-inflammatory and immunosuppressive drugs but their application is hampered by
    Ramachandran Venkitaraman et al.
    European urology, 67(4), 673-679 (2014-12-03)
    Prednisolone is widely used as secondary hormonal treatment for castration-resistant prostate cancer (CRPC). We hypothesised that dexamethasone, another corticosteroid, is more active. To compare the activity of prednisolone and dexamethasone in CRPC. This single-centre, randomised, phase 2 trial was performed
    Murat Baş et al.
    The New England journal of medicine, 372(5), 418-425 (2015-01-30)
    Angioedema induced by treatment with angiotensin-converting-enzyme (ACE) inhibitors accounts for one third of angioedema cases in the emergency room; it is usually manifested in the upper airway and the head and neck region. There is no approved treatment for this
    View All Related Papers

    Global Trade Item Number

    SKUGTIN
    BP46404061835278060