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G5882

Sigma-Aldrich

Glutaraldehyde solution

Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative

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Synonym(s):
Glutaric dialdehyde solution, Pentane-1,5-dial
Linear Formula:
OHC(CH2)3CHO
CAS Number:
111-30-8
Molecular Weight:
100.12
Beilstein:
605390
MDL number:
MFCD00007025
PubChem Substance ID:
24895235
NACRES:
NA.21

Quality Level

300

type

Grade I

concentration

25% in H2O

technique(s)

electron microscopy: suitable (fixative)

color

colorless

useful pH range

2.9

mp

-10 °C ((14 °F ))

solubility

water: soluble at 20 °C

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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General description

Glutaraldehyde, a saturated dialdehyde, is a high-level disinfectant and a chemical sterilant. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties.

Application

Glutaraldehyde solution has been used:
  • to fix the blood samples for scanning electron microscopy (SEM)
  • to fix scaffold pieces for SEM analysis
  • in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components

Biochem/physiol Actions

Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.

Features and Benefits

  • Safe to use with lensed instruments, rubber, or plastics
  • Non-corrosive to metal

Other Notes

Recommended for techniques demanding high purity.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH071

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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