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M8277

Midodrine hydrochloride

Name: Midodrine hydrochloride
Brand: SIAL

analytical standard, for drug analysis

Synonym(s):

(±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₈N₂O₄ · HCl

CAS Number:

3092-17-9

Molecular Weight:

290.74

NACRES:

NA.24

PubChem Substance ID:

329818055

UNSPSC Code:

41116107

MDL number:

MFCD00079455

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Properties

Quality Level

100

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

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A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome.

Amanda J Ross et al.

Clinical science (London, England : 1979), 126(4), 289-296 (2013-08-28)

POTS (postural tachycardia syndrome) is a chronic form of OI (orthostatic intolerance). Neuropathic POTS is characterized by decreased adrenergic vasoconstriction, whereas hyperadrenergic POTS exhibits increased adrenergic vasoconstriction. We hypothesized that midodrine, an α1-adrenergic receptor agonist, would increase CVR (calf vascular

Determination of midodrine in human plasma by high-performance liquid chromatography with fluorescence detection

Yoshida H, et al.

Analytical Sciences, 19(2), 317-319 (2003)

Effectiveness of midodrine treatment in patients with recurrent vasovagal syncope not responding to non-pharmacological treatment (STAND-trial).

Jacobus J C M Romme et al.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 13(11), 1639-1647 (2011-07-15)

Initial treatment of vasovagal syncope (VVS) consists of advising adequate fluid and salt intake, regular exercise, and physical counterpressure manoeuvres. Despite this treatment, up to 30% of patients continue to experience regular episodes of VVS. We investigated whether additional Midodrine

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Global Trade Item Number

SKU	GTIN
M8277-1G	04061826762257
M8277-50MG	04061833652596