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T1300000

Thioridazine hydrochloride

Name: Thioridazine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₆N₂S₂ · HCl

CAS Number:

130-61-0

Molecular Weight:

407.04

NACRES:

NA.24

PubChem Substance ID:

329826662

UNSPSC Code:

41116107

MDL number:

MFCD00012655

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Properties

grade

pharmaceutical primary standard

API family

thioridazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1

InChI

1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

InChI key

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Thioridazine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis.

Amandeep Singh et al.

Tuberculosis (Edinburgh, Scotland), 94(6), 695-700 (2014-10-12)

Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine potentiated the activities of both isoniazid and rifampicin (>1 log CFU reduction) against the in vitro latent Mycobacterium tuberculosis bacilli. Further, a murine

Experimentally validated HERG pharmacophore models as cardiotoxicity prediction tools.

Jadel M Kratz et al.

Journal of chemical information and modeling, 54(10), 2887-2901 (2014-08-26)

The goal of this study was to design, experimentally validate, and apply a virtual screening workflow to identify novel hERG channel blockers. The hERG channel is an important antitarget in drug development since cardiotoxic risks remain as a major cause

Global Trade Item Number

SKU	GTIN
T1300000	04061833801123