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U5128

Urea

Name: Urea
Brand: SIAL

ACS reagent, 99.0-100.5%

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Synonym(s):

Carbamide, Carbonyldiamide

Linear Formula:

NH₂CONH₂

CAS Number:

57-13-6

Molecular Weight:

60.06

Beilstein:

635724

EC Number:

200-315-5

MDL number:

MFCD00008022

PubChem Substance ID:

24900652

NACRES:

NA.21

grade

ACS reagent

Quality Level

200

Assay

99.0-100.5%

form

solid

impurities

≤0.01% Insoluble matter

ign. residue

≤0.01%

mp

132-135 °C (lit.)

solubility

H₂O: soluble 480 g/L at 20 °C

density

1.335 g/mL at 25 °C (lit.)

anion traces

chloride (Cl^-): ≤5 ppm
sulfate (SO₄^2-): ≤0.001%

cation traces

Fe: ≤0.001%
heavy metals (as Pb): ≤0.001%

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

Gene Information

human ... CA1(759) , CA2(760)
rat ... Ppm1a(24666)

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Organic Building Blocks

General description

Urea is a colourless organic compound, without any odour. It is easily soluble in water.

Application

Urea has been used:

to adjust the urea nitrogen concentration to a preferred range in blood reservoir for evaluating the dialyzer urea clearance
to prepare standards to measure urea synthesis
to prepare standards for blood urea nitrogen assay

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Biochem/physiol Actions

Urea participates in the metabolism of nitrogenous substances. It serves as a nitrogen source, when used in fertilizers. Urea is used in manufacturing chemical compounds. It is widely used in the agricultural industry as a fertilizer as well as an animal feed additive, which is used as a nitrogen supplement in animal husbandry. Urea has adverse effects on seed germination, seedling growth and early plant growth in soil.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Elimination of the adverse effects of urea fertilizer on seed germination, seedling growth, and early plant growth in soil

Bremner JM and Krogmeier MJ

Proceedings of the National Academy of Sciences of the USA, 85(13), 4601-4604 (1988)

Urea: Synthesis, Properties and Uses (2012)

Transplantation of bone marrow-derived MSCs improves cisplatinum-induced renal injury through paracrine mechanisms

Cheng K, et al.

Experimental and Molecular Pathology, 94(3), 466-473 (2013)

CHAPTER 16 - METHODS OF FEEDING UREA TO LIVESTOCK

Urea As a Protein Supplement, 321-327 (1967)

Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates

Leypoldt JK, et al.

Kidney International, 51(6), 2013-2017 (1997)

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