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Sigma-Aldrich

Copper(II) sulfate pentahydrate

ACS reagent, ≥98.0%

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Synonym(s):
Blue Vitriol, Cupric sulfate pentahydrate, Sulfuric acid, copper(II) salt (1:1) pentahydrate
Linear Formula:
CuSO4 · 5H2O
CAS Number:
7758-99-8
Molecular Weight:
249.69
EC Number:
231-847-6
MDL number:
MFCD00149681
PubChem Substance ID:
329752057
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

vapor pressure

7.3 mmHg ( 25 °C)

Assay

≥98.0%
98.0-102.0% (ACS specification)

form

crystals

reaction suitability

reaction type: click chemistry
reagent type: catalyst
core: copper

pH

3.5-4.5 (20 °C, 50 g/L)

mp

110 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤0.001%

cation traces

Ca: ≤0.005%
Fe: ≤0.003%
K: ≤0.01%
Na: ≤0.02%
Ni: ≤0.005%

SMILES string

O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O

InChI

1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2

InChI key

JZCCFEFSEZPSOG-UHFFFAOYSA-L

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General description

Copper(II) sulfate pentahydrate is a Lewis acid catalyst commonly used to promote acid-catalyzed organic transformations. It can also act as an effective redox catalyst in combination with other mixed oxidizing agents.

Application

Copper(II) sulfate pentahydrate can be used as a catalyst:      
  • In acetylation of alcohols and phenols in the presence of acetic anhydride.      
  • To synthesize various ynamides via intramolecular coupling of amides with alkynyl bromides.

It can also be used as a template in the synthesis of copper(II) ion-imprinted polymers using vinylpyridine and methacrylic acid as functional monomers. This polymer is used to quantify Cu2+ ion by using flame atomic absorption spectroscopy.

Features and Benefits

CuSO4.5H2O is an inexpensive, safe catalyst to be used in various organic transformations. It can also be recovered and reused in another reaction.

Signal Word

Danger

Hazard Statements

H302 - H318 - H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Wei Zhao et al.
Dalton transactions (Cambridge, England : 2003), (8)(8), 1509-1517 (2005-04-13)
Three novel metal-organic frameworks (MOFs), [Cu(1)SO4].H2O (4), [Cu2(2)2(SO4)2].4H2O (5) and [Cu(3)(H2O)]SO4.5.5H2O (6), were obtained by hydrothermal reactions of CuSO4.5H2O with the corresponding ligands, which have different flexibility. The structures of the synthesized complexes were determined by single-crystal X-ray diffraction analyses.
Copper (II) sulfate pentahydrate (CuSO4. 5H2O): a green catalyst for solventless acetylation of alcohols and phenols with acetic anhydride.
Heravi MM, et al.
Journal of the Brazilian Chemical Society, 17(5), 1045-1047 (2006)
Damijana Urankar et al.
Journal of combinatorial chemistry, 10(6), 981-985 (2008-10-17)
Azoamides, previously established as bioactive intracellular GSH-depleting agents, were decorated with a terminal alkyne moiety to 4 and then were transformed, by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), into different ligand-arm functionalized azoamides 6. Azides 5 having ligand-arms amenable for binding to
Preparation of Cu2ZnSnS4 thin films by sulfurization of co-electroplated Cu-Zn-Sn precursors.
Araki H, et al.
Physica Status Solidi, 6(5), 1266-1268 (2009)
Bhagwan S Batule et al.
International journal of nanomedicine, 10 Spec Iss, 137-142 (2015-09-09)
We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein
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