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275R-1

Ki-67 (SP6) Rabbit Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP6, monoclonal
Application:
IHC (p)
Citations:
6
Technical Service
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biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP6, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (275R-14), vial of 0.5 mL concentrate (275R-15), bottle of 1.0 mL predilute (275R-17), vial of 1.0 mL concentrate (275R-16), bottle of 7.0 mL predilute (275R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... MKI67(4288)

General description

The Ki-67 antigen is a nuclear, non-histone protein that is present in proliferatingcells. Though its specific role is largely postulated and still yet to be determined,Ki-67’s presence during cellular division makes it an excellent target for labeling rapidlygrowing malignancies. Given that its presence correlates with cell proliferation, theimmunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion’sgrowth fraction.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
1420502A-Z
1506501A-Z

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Protocols

Generating Organotypic Air-Liquid Interface (ALI) 3D Skin Cultures as an In-Vitro Model of the Human Epidermis

3D cell culture protocol for generating epidermal human skin tissue using primary human keratinocytes, dermal fibroblasts, and collagen-coated transwell inserts.

Articles

胃肠道癌症中的免疫组织化学应用

结直肠癌是男性和女性中第三大常见癌症。预计2016年将发生136,000例结直肠癌。

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

Related Content

诊断性免疫组化操作步骤

诊断性免疫组化是一系列用于识别组织异常、建立预后并提示治疗方式的技术。其基本原理是一种抗原-抗体结合反应，利用酶或荧光染料来标记抗体，呈现出组织或组织切片中特定抗原的位置和分布。

Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Swerdlow S, et al. WHO clarifications of tumours of hematopoietic and lymphoid tissues. 4th edition, 2008. P 220.
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 220-220 (2008)
P E McKeever et al.
Journal of neuropathology and experimental neurology, 57(10), 931-936 (1998-10-24)
The purpose of this study was to determine whether a relationship existed between MIB-1 labeling index (LI) percentages and survival in patients with grade II astrocytomas. From archival paraffin-embedded surgical specimens of 50 patients of the University of Michigan Medical
S W Coons et al.
Neurosurgery, 41(4), 878-884 (1997-10-08)
The prognostic significance of quantitative measurement of tumor proliferative activity was evaluated for oligodendroglial tumors. Ki-67/MIB-1 immunochemistry was used to measure proliferative activity in 81 oligodendrogliomas and oligoastrocytomas. The relationship among survival, proliferation, histological features, and clinical variables were evaluated
View All Related Papers

Global Trade Item Number

SKUGTIN
275R-170841683132325
275R-180841683132332
275R-140841683132295
275R-150841683132301
275R-160841683132318