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51120

Guanosine 5′-triphosphate sodium salt hydrate

Name: Guanosine 5&#8242;-triphosphate sodium salt hydrate
Brand: SIGMA

≥90% (HPLC), powder

Synonym(s):

GTP, GTP-Na⁺ hydrate, 5′-GTP-Na₂

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₅O₁₄P₃ · xNa⁺ · yH₂O

CAS Number:

56001-37-7

Molecular Weight:

523.18 (anhydrous free acid basis)

NACRES:

NA.51

PubChem Substance ID:

57651277

UNSPSC Code:

41106305

EC Number:

252-847-2

MDL number:

MFCD00149227

Beilstein/REAXYS Number:

4113439

Assay:

≥90% (HPLC)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Properties

Product Name

Guanosine 5′-triphosphate sodium salt hydrate, ≥90% (HPLC)

Quality Level

100

assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in 0.5 M Na₂HPO₄

impurities

≤3 mol/mol water (NMR)

solubility

water: 50 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

Description

General description

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:

as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
in a solution for channel current recording in cell lines using a voltage-clamp technique.
to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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