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53048

5-Carboxy-tetramethylrhodamine N-succinimidyl ester

Name: 5-Carboxy-tetramethylrhodamine <I>N</I>-succinimidyl ester
Brand: SIGMA

BioReagent, suitable for fluorescence

Synonym(s):

"4-Carboxytetramethylrhodamine N-succinimidyl ester", 5-TAMRA

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₂₅N₃O₇

CAS Number:

150810-68-7

Molecular Weight:

527.52

NACRES:

NA.32

PubChem Substance ID:

57651396

UNSPSC Code:

12352116

MDL number:

MFCD03453223

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Properties

product line

BioReagent

Quality Level

100

solubility

DMF: soluble, acetonitrile: soluble

fluorescence

λ_ex 543 nm; λ_em 578 nm in 0.1 M phosphate pH 7.0

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CN(C)c1ccc2c(OC3=C\C(C=CC3=C2c4ccc(cc4C([O-])=O)C(=O)ON5C(=O)CCC5=O)=[N+](\C)C)c1

InChI

1S/C29H25N3O7/c1-30(2)17-6-9-20-23(14-17)38-24-15-18(31(3)4)7-10-21(24)27(20)19-8-5-16(13-22(19)28(35)36)29(37)39-32-25(33)11-12-26(32)34/h5-10,13-15H,11-12H2,1-4H3

InChI key

VWFRSNKRTNUMET-UHFFFAOYSA-N

Description

Application

5-Carboxy-tetramethylrhodamine N-succinimidyl ester (5-TAMRA) is used as an amine coupling reagent to form 5-carboxy-tetramethylrhodamine (5-TAMRA) derivatized compounds. 5-TAMRA derivatized compounds may be used in applications as enzyme substrates, molecular probes, molecular beacons and as fluorescence resonance energy transfer (FRET) partners.

Other Notes

Fluorescent labeling of DNA and RNA

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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An αB-Crystallin Peptide Rescues Compartmentalization and Trafficking Response to Cu Overload of ATP7B-H1069Q, the Most Frequent Cause of Wilson Disease in the Caucasian Population.

Simona Allocca et al.

International journal of molecular sciences, 19(7) (2018-06-30)

The H1069Q substitution is the most frequent mutation of the Cu transporter ATP7B that causes Wilson disease in the Caucasian population. ATP7B localizes to the Golgi complex in hepatocytes, but, in the presence of excessive Cu, it relocates to the

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.

Erki Enkvist et al.

Organic & biomolecular chemistry, 10(43), 8645-8653 (2012-10-04)

Up-regulation of an acidophilic protein kinase, CK2, has been established in several types of cancer. This cognition has made CK2 an important target for drug development for cancer chemotherapy. The characterization of potential drug candidates, determination of the structure and

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK.

Angela Vaasa et al.

Analytical biochemistry, 385(1), 85-93 (2008-11-20)

The bisubstrate fluorescent probe ARC-583 (Adc-Ahx-(D-Arg)(6)-d-Lys(5-TAMRA)-NH2) and its application for the characterization of both ATP- and protein/peptide substrate-competitive inhibitors of protein kinases PKA (cyclic AMP-dependent protein kinase) and ROCK (rho kinase) in fluorescence polarization-based assay are described. High affinity of

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Global Trade Item Number

SKU	GTIN
53048-5MG-F	04061837732331
53048-1MG-F	04061823354424