A0788
3-Aminobenzamide
≥99% (TLC), PARP inhibitor, powder
Synonym(s):
3-AB, 3-ABA
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About This Item
Linear Formula:
H2NC6H4CONH2
CAS Number:
Molecular Weight:
136.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
222-586-9
MDL number:
Assay:
≥99% (TLC)
Form:
powder
Product Name
3-Aminobenzamide, ≥99% (TLC)
assay
≥99% (TLC)
form
powder
color
white to off-white
mp
115-116 °C (lit.)
solubility
ethanol: 50 mg/mL, clear, light yellow, DMSO: soluble, H2O: soluble (may require gentle heating)
storage temp.
room temp
SMILES string
NC(=O)c1cccc(N)c1
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
Gene Information
mouse ... Parp1(11545)
Application
3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.
Biochem/physiol Actions
3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.