A3773
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate
≥99%
Synonym(s):
THA hydrochloride hydrate, Tacrine hydrochloride, Tetrahydroaminacrine hydrochloride hydrate
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About This Item
Empirical Formula (Hill Notation):
C13H14N2 · HCl · xH2O
CAS Number:
Molecular Weight:
234.72 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Features and Benefits
This compound is featured on the Acetylcholine Synthesis and Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Danger
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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M Harel et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(19), 9031-9035 (1993-10-01)
Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edrophonium, and quaternary nitrogen of the ligand
Go Koganemaru et al.
Pharmacology, biochemistry, and behavior, 126, 103-108 (2014-09-30)
We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats. Rats received intraperitoneal injection of cabergoline (0.5, 1.0, or 5.0mg/kg), rotigotine (1.0, 2.5, or 10.0mg/kg), or vehicle 30min before intraperitoneal injection
Jinggong Liu et al.
Biochimica et biophysica acta, 1840(9), 2886-2903 (2014-05-14)
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that is characterized by dementia, cognitive impairment, and memory loss. Diverse factors are related to the development of AD, such as increased level of β-amyloid (Aβ), acetylcholine, metal ion deregulation, hyperphosphorylated
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3773-10G | 04061832945248 |
| A3773-5G | 04061832945255 |
| A3773-1G | 04061833367889 |