B112
(±)-Bay K8644
≥97.5% (HPLC), Calcium channel agonist, powder
Synonym(s):
1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester
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About This Item
Empirical Formula (Hill Notation):
C16H15F3N2O4
CAS Number:
Molecular Weight:
356.30
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
(±)-Bay K8644, calcium channel agonist
Quality Level
assay
≥97.5% (HPLC)
form
powder
color
yellow to dark yellow
mp
168-170 °C
solubility
DMSO: 20 mg/mL, methanol and ethanol: 63 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
CC1=C(C(OC)=O)C(C2=CC=CC=C2C(F)(F)F)C([N+]([O-])=O)=C(C)N1
InChI
1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChI key
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
Gene Information
rat ... Cacna1c(24239)
Application
(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.
Biochem/physiol Actions
(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it′s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.
Increases influx of Ca2+ specifically at voltage-gated calcium channels.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The calcium channel agonist BAY k 8644 reduces ethanol intake and preference in alcohol-preferring AA rats
de Beun R, et al.
Psychopharmacology, 127(1-2), 302-310 (1996)
Identification and mechanosensitivity of viscerofugal neurons
Hibberd TJ, et al.
Neuroscience, 225(8), 118-129 (2012)
Calcium channel antagonist properties of Bay K 8644 in single guinea pig ventricular cells.
Hadley, RW and Hume, JR
Circulation Research, 62(1), 97-104 (1988)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B112-25MG | 04061832945330 |
| B112-5MG | 04061833420898 |