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About This Item
Biological source:
human (iPSC line)
biological source
human (iPSC line)
form
frozen liquid
packaging
vial of 1 (contains ≥1 million cells)
technique(s)
cell culture | mammalian: suitable
shipped in
liquid nitrogen
storage temp.
-140 to -196°C
General description
Human iPSC-Derived Microglia. Cells derived from male (BX-0900-30-1M) and female (BX-0900-32-1M) lines available. GFP-expressing neurons also available (BX-0901-30-1M). A major immune cell within the central nervous system (CNS), microglia are responsible for eliminating dead neurons, microbes, protein aggregates, and other particulates like degenerating synapses and myelin debris that are in the CNS. They also help to maintain neuronal networks, aid in injury repair, and mediate neuroinflammation. Microglia are implicated in neurodegeneration and aging, and are used to study autism, epilepsy, Alzheimer’s disease, and Huntington’s disease.
Application
Function: Human Microglia demonstrate phagocytosis and can be stimulated to secrete a variety of cytokines.
Features and Benefits
Marker Expression: Fully differentiated with confirmed expression of microglia surface markers including: CD45, CD11b, CX3CR1, P2RY12, and TMEM119. Immunocytochemistry shortly after plating microglia (shown here with a DAPI stain) reveals prominent expression of TREM2 (green) and IBA1 (red).
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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