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C1129

Cholic acid

Name: Cholic acid
Brand: SIGMA

from bovine and/or ovine, ≥98%

Synonym(s):

3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₄₀O₅

CAS Number:

81-25-4

Molecular Weight:

408.57

UNSPSC Code:

12161900

NACRES:

NA.25

PubChem Substance ID:

24892356

EC Number:

201-337-8

Beilstein/REAXYS Number:

2822009

MDL number:

MFCD00003672

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Properties

biological source

bovine and/or ovine

Quality Level

200

description

anionic

assay

≥98%

form

powder

mol wt

408.57 g/mol

mp

200-201 °C (lit.)

solubility

water: soluble 0.175 g/L at 25 °C

application(s)

pharmaceutical

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O

InChI

1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

InChI key

BHQCQFFYRZLCQQ-OELDTZBJSA-N

Gene Information

human ... CYP1A2(1544)

Description

General description

Cholic acid is a major primary bile acid produced in the liver which facilitates fat absorption and cholesterol excretion. It is a non-denaturing ionic detergent.

Application

Dietary cholic acid has been used in a study to assess its effect on colonic epithelial cell proliferation. It has also been used in a study to investigate extractions and comparisons of human erythrocyte ghosts.

Non-denaturing ionic detergent used for extraction of membrane proteins.

Biochem/physiol Actions

Bile Acid

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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Protocols

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.