C2105
Z-Val-Ala-Asp fluoromethyl ketone
≥90% (TLC), Caspase-1 inhibitor, powder
Synonym(s):
Z-VAD-FMK, Non-methylated
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About This Item
Empirical Formula (Hill Notation):
C21H28FN3O7
CAS Number:
Molecular Weight:
453.46
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Z-Val-Ala-Asp fluoromethyl ketone, powder, ≥90% (TLC)
Quality Level
assay
≥90% (TLC)
form
powder
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI
1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1
InChI key
SUUHZYLYARUNIA-YEWWUXTCSA-N
Biochem/physiol Actions
Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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