C8417
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
≥98% (TLC), solid, adrenergic neurotoxin
Synonym(s):
DSP-4, N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C11H15BrClN · HCl
CAS Number:
Molecular Weight:
313.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Beilstein/REAXYS Number:
4020910
Product Name
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, ≥98%, solid
Quality Level
assay
≥98%
form
solid
color
white
solubility
H2O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble
SMILES string
Cl[H].CCN(CCCl)Cc1ccccc1Br
InChI
1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
InChI key
NDDRNRRNYOULND-UHFFFAOYSA-N
Biochem/physiol Actions
Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.
Preparation Note
Solutions in ethanol, water or 0.1 N NaOH should be freshly prepared.
Disclaimer
Hygroscopic.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
P Szot et al.
Neuroscience, 166(1), 279-291 (2010-01-05)
Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the consequence of noradrenergic neuronal loss has different effects on the surviving neurons in the two disorders. Therefore
Ee Peng Lim et al.
The international journal of neuropsychopharmacology, 13(9), 1219-1231 (2010-02-05)
Stimulation of the subiculum/CA1 of the hippocampal formation evokes monosynaptic field potentials in the prefrontal cortex (PFC). High-frequency stimulation of the hippocampus (HPC) can induce long-term potentiation (LTP) in this hippocampo-prefrontal cortical (hippo-PFC) pathway. Previous studies have shown that dopamine
Harald Engler et al.
Journal of neuroimmunology, 219(1-2), 75-80 (2009-12-25)
The neurotransmitter noradrenaline (NA) plays a pivotal role in immune regulation. Here we used the selective neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to investigate the impact of central NA depletion on cytokine production by splenic monocytes/macrophages and T cells. Intraperitoneal administration of DSP-4
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8417-100MG | 04061833522295 |
| C8417-250MG | 04061832090009 |