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C9867

CGK733

Name: CGK733
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-3-nitrophenyl)thioureido]ethyl)acetamide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₁₈Cl₃FN₄O₃S

CAS Number:

905973-89-9

Molecular Weight:

555.84

NACRES:

NA.77

PubChem Substance ID:

24724454

UNSPSC Code:

12352200

MDL number:

MFCD09038682

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F

InChI

1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)

InChI key

HLCDNLNLQNYZTK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Originally published as a selective ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase inhibitor, which causes reversible reprogramming of cellular lifespan, conferred robust growth to senescent cells that had ceased proliferation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.

Olga V Leontieva et al.

Aging, 3(11), 1078-1091 (2011-12-14)

In yeast, chronological senescence (CS) is defined as loss of viability in stationary culture. Although its relevance to the organismal aging remained unclear, yeast CS was one of the most fruitful models in aging research. Here we described a mammalian

Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression.

Yi Na Jiang et al.

Experimental cell research, 381(2), 165-171 (2019-05-18)

Matrix metalloproteinases (MMPs) and the epithelial-mesenchymal transition (EMT) contribute to metastasis. As shown in our previous studies, interleukin-6 (IL-6) induces ATM phosphorylation to increase MMP expression and metastasis in lung cancer. However, the exact roles of ATM activation in the

Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase δ.

Ling Hui Xu et al.

The Journal of biological chemistry, 286(45), 39546-39559 (2011-09-16)

Perturbation of cell cycle regulation is a characteristic feature of infection by many DNA and RNA viruses, including Coronavirus infectious bronchitis virus (IBV). IBV infection was shown to induce cell cycle arrest at both S and G(2)/M phases for the

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Global Trade Item Number

SKU	GTIN
C9867-25MG	04061832283906
C9867-5MG	04061832445335