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CNSBR006

Ionomycin from Streptomyces conglobatus

Name: Ionomycin from <I>Streptomyces conglobatus</I>
Brand: SIGMA

≥98% (HPLC), liquid

Synonym(s):

Kanamycin A, Kanamycin sulfate salt

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₇₂O₉

CAS Number:

56092-81-0

Molecular Weight:

709.00

UNSPSC Code:

51101500

Beilstein/REAXYS Number:

3642126

MDL number:

MFCD06798385

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Properties

Quality Level

200

assay

≥98% (HPLC)

form

liquid

color

, light yellow to brown

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

storage temp.

−20°C

SMILES string

C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1

InChI key

PGHMRUGBZOYCAA-ADZNBVRBSA-N

Description

Application

Ionomycin from Streptomyces conglobatus has been used:

in magnesium-ionomycin treatment experiments
as a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatment
in the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM)
as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

Biochem/physiol Actions

Ionomycin is a polyether antibiotic and an ionophore produced by the bacterium Streptomyces conglobatus. This Ca²⁺ ionophore is more effective than A23187 as a mobile ion carrier for Ca⁺. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons. Ionomycin has been shown to induce central demyelination, inhibit adrenal bovine TREK-1 channels, and regulate cell division of mature human B cells. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress, and intrinsic apoptosis mechanisms. It also stimulates the intracellular production of cytokines, interferon, perforin, interleukin-2 (IL-2), and IL-4 usually in conjunction with PMA. Ionomycin is highly specific for divalent cations. It may have antiproliferative effects on the human bladder cancer cell line both in vitro and in vivo. Ionomycin functions as an apoptosis inducer which was suggested to act by activation of a latent, calcium-responsive endonuclease.

Features and Benefits

High quality antibiotic suitable for mulitple research applications.

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Storage Class

10 - Combustible liquids

Regulatory Information

涉药品监管产品

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Global Trade Item Number

SKU	GTIN
CNSBR006-1MG	04065272682015