Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Linear Formula:
CH3(CH2)11N(CH3)3Br
CAS Number:
Molecular Weight:
308.34
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
EC Number:
214-290-3
Beilstein/REAXYS Number:
3597463
MDL number:
biological source
synthetic (oragnic)
description
cationic
assay
≥98%
form
powder
mol wt
308.34 g/mol
mp
246 °C (dec.) (lit.)
solubility
954 g/L at 20 °C
density
1.17 g/cm3 at 20 °C (68 °F)
application(s)
(Solubilizing proteins, cell lysis)
SMILES string
[Br-].CCCCCCCCCCCC[N+](C)(C)C
InChI
1S/C15H34N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16(2,3)4;/h5-15H2,1-4H3;1H/q+1;/p-1
InChI key
XJWSAJYUBXQQDR-UHFFFAOYSA-M
General description
Dodecyltrimethylammonium bromide (DTAB) is a versatile quaternary ammonium surfactant with a wide range of applications in cell biology and biochemical research. Its unique properties make it a valuable tool for solubilizing proteins and peptides, extracting DNA, and lysing cells. In proteomics research, DTAB plays a crucial role in protein solubilization and purification. Its ability to disrupt hydrophobic interactions and electrostatic forces allows it to effectively solubilize membrane-bound proteins and peptides, making them accessible for analysis and characterization. This property is particularly important in proteomics studies involving membrane proteins, which are often difficult to solubilize using conventional methods.
Beyond protein solubilization, this cationic detergent also finds application in DNA extraction procedures. Its ability to interact with DNA and alter its conformation facilitates the release of DNA from cellular components, enabling its subsequent purification and analysis. This property is particularly useful in the isolation of DNA from various biological samples, including tissues, cells, and microorganisms. Furthermore, DTAB demonstrates effectiveness in cell lysis processes. Its ability to disrupt cell membranes and release intracellular components makes it a valuable tool for breaking down cells and accessing their contents. This property has applications in various biological studies, including protein extraction, enzyme assays, and cellular component analysis.
Dodecyltrimethylammonium bromide (DTAB) stands as a versatile and widely applicable surfactant with a diverse range of applications in proteomics research, cell biology, and biochemical research. Its ability to solubilize proteins and peptides, extract DNA, and lyse cells makes it an essential tool for various biological studies and analytical techniques.
Beyond protein solubilization, this cationic detergent also finds application in DNA extraction procedures. Its ability to interact with DNA and alter its conformation facilitates the release of DNA from cellular components, enabling its subsequent purification and analysis. This property is particularly useful in the isolation of DNA from various biological samples, including tissues, cells, and microorganisms. Furthermore, DTAB demonstrates effectiveness in cell lysis processes. Its ability to disrupt cell membranes and release intracellular components makes it a valuable tool for breaking down cells and accessing their contents. This property has applications in various biological studies, including protein extraction, enzyme assays, and cellular component analysis.
Dodecyltrimethylammonium bromide (DTAB) stands as a versatile and widely applicable surfactant with a diverse range of applications in proteomics research, cell biology, and biochemical research. Its ability to solubilize proteins and peptides, extract DNA, and lyse cells makes it an essential tool for various biological studies and analytical techniques.
Application
Dodecyltrimethylammonium bromide has been used in a study to assess the distribution of binary mixed counterions in surfactant adsorbed films. It has also been used in a study to investigate chain length compatibility of surfactants for extraction of organophosphorous pesticides.
Dodecyltrimethylammonium bromide has been used to lyse neonatal normal human epidermal keratinocyte (NHEK) cells for the quantification of intracellular nicotinamide adenine dinucleotide phosphate (NADP+) and NADPH (reduced form) content.
Features and Benefits
High-quality compound for your cell biology and biochemical research
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Still not finding the right product?
Explore all of our products under Dodecyltrimethylammonium bromide
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Study on the distribution of binary mixed counterions in surfactant adsorbed films by total reflection XAFS measurements
Y Imai et al.
Journal of Colloid and Interface Science, 15, 219-224 (2012)
Xiaofeng Chang et al.
Journal of colloid and interface science, 377(1), 291-298 (2012-04-28)
This study reported, for the first time systematically, photodegradation of Rhodamine B (RhB) in aqueous solution over BiOCl and BiOBr semiconductors. Under visible light irradiation (λ>400 nm, λ>420 nm and λ=550±15 nm), RhB adsorbed on the surface of BiOCl and
Jonas Carlstedt et al.
Physical chemistry chemical physics : PCCP, 14(27), 9574-9577 (2012-06-14)
Polyelectrolytes with amphiphilic counterions, PEACs, are water insoluble because the amphiphiles self-assemble into highly charged micelles that strongly associate with the equally highly charged polyions. However, in the presence of water soluble cyclodextrins (CDs) that form inclusion complexes with the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D8638-100G | 04061835544202 |
| D8638-25G | 04061835544219 |