Erythromycin stearate

Name: Erythromycin stearate
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₃₇H₆₇NO₁₃ · C₁₈H₃₆O₂

CAS Number:

643-22-1

Molecular Weight:

1018.40

UNSPSC Code:

41116107

PubChem Substance ID:

24894693

EC Number:

211-396-1

MDL number:

MFCD00084690

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Properties

biological source

synthetic

form

solid

color

white to off-white

solubility

ethanol: 50 mg/mL, clear to very slightly hazy, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCCCCCCCC(O)=O.CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@H](C)C(=O)C(C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13.C18H36O2/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-17H2,1H3,(H,19,20)/t18-,19+,20?,21+,22-,23-,24-,25-,26-,28+,29+,30+,31-,32-,34-,35-,36+,37?;/m0./s1

InChI key

YAVZHCFFUATPRK-JGJPHTNUSA-N

Description

General description

Chemical structure: macrolide

Application

Erythromycin stearate is used to study leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. It is also used to study abnormal polymorphonuclear leucocyte migration and chemotaxis.

Biochem/physiol Actions

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).