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CN

EHU160521

MISSION® esiRNA

targeting human SIRT2

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NACRES:
NA.51
UNSPSC Code:
41105324
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description

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Quality Level

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTC

Ensembl | human accession no.

NCBI accession no.

shipped in

ambient

storage temp.

−20°C

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany


Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Fang-Fang He et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(2), 451-460 (2018-04-04)
Renal tubular epithelial cells and fibroblasts are the main sources of myofibroblasts, and these cells produce the extracellular matrix during tubulointerstitial fibrosis (TIF). Histone deacetylases (HDAC) inhibitors exert an antifibrogenic effect in the skin, liver and lung. Sirtuin 2 (SIRT2)
Chin-Wei Liu et al.
Chemico-biological interactions, 289, 98-108 (2018-04-22)
Breast cancer is a major public health problem throughout the world. In this report, we investigated whether CHM-1, a novel synthetic antimitotic agent could be developed into a potent antitumor agent for treating human breast cancer. CHM-1 induced growth inhibition
Phuongmai Nguyen et al.
Radiation research, 191(5), 398-412 (2019-03-06)
Sirtuin 2 (SIRT2) plays a major role in aging, carcinogenesis and neurodegeneration. While it has been shown that SIRT2 is a mediator of stress-induced cell death, the mechanism remains unclear. In this study, we report the role of SIRT2 in



Global Trade Item Number

SKUGTIN
EHU160521-20UG04061828657483
EHU160521-50UG04061828431632