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F1678

R-(−)-Fluoxetine hydrochloride

Name: R-(−)-Fluoxetine hydrochloride
Brand: SIGMA

>98% (HPLC), solid

Synonym(s):

(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈NOF₃ · HCl

CAS Number:

114247-09-5

Molecular Weight:

345.79

NACRES:

NA.77

PubChem Substance ID:

24278433

UNSPSC Code:

12352200

MDL number:

MFCD04040065

Assay:

>98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: soluble >10 mg/mL

originator

Eli Lilly

SMILES string

Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1

InChI key

GIYXAJPCNFJEHY-PKLMIRHRSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Description

Application

R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:

to study its effects on the embryoid body (EB) morphogenesis
in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
to study its effects as an endocrine disruption inducer in Pimephales promelas

Biochem/physiol Actions

Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.

Selective serotonin reuptake inhibitor.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H315,H318

pcodes

P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c