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F3379

Fibrinopeptide B human

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C66H93N19O25
CAS Number:
36204-23-6
Molecular Weight:
1552.56
UNSPSC Code:
12352200
PubChem Substance ID:
24894841
MDL number:
MFCD00076439
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biological source

human

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P02675

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)CNC(=O)C1CCC(=O)N1)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(O)=O

InChI

1S/C66H93N19O25/c1-31(2)53(85-49(91)29-73-55(99)35-16-19-47(89)75-35)64(108)83-42(26-46(68)88)61(105)82-43(27-52(96)97)62(106)81-41(25-45(67)87)60(104)78-37(18-21-51(94)95)57(101)77-36(17-20-50(92)93)56(100)72-28-48(90)76-39(23-33-11-6-4-7-12-33)58(102)80-40(24-34-13-8-5-9-14-34)59(103)84-44(30-86)63(107)74-32(3)54(98)79-38(65(109)110)15-10-22-71-66(69)70/h4-9,11-14,31-32,35-44,53,86H,10,15-30H2,1-3H3,(H2,67,87)(H2,68,88)(H,72,100)(H,73,99)(H,74,107)(H,75,89)(H,76,90)(H,77,101)(H,78,104)(H,79,98)(H,80,102)(H,81,106)(H,82,105)(H,83,108)(H,84,103)(H,85,91)(H,92,93)(H,94,95)(H,96,97)(H,109,110)(H4,69,70,71)

InChI key

MYRIFIVQGRMHRF-UHFFFAOYSA-N

Gene Information

human ... FGB(2244)

General description

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.

Biochem/physiol Actions

Cleavage of fibrinopeptide B from fibrinogen Bβ chains exposes E domain polymerization sites, E(B), that interact with platelets, fibroblasts and endothelial cells.
Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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