F8807
FM19G11
≥98% (HPLC)
Synonym(s):
3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester, [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
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About This Item
Empirical Formula (Hill Notation):
C23H17N3O8
CAS Number:
Molecular Weight:
463.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: ≥40 mg/mL
storage temp.
2-8°C
SMILES string
Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI
1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
InChI key
XVUOIWIIQVGWAJ-UHFFFAOYSA-N
Application
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factor α (HIFα), reported to affect self-renewal and differentiation of stem cells.
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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UV-protection timer controls linkage between stress and pigmentation skin protection systems
Malcov B, et al.
Molecular Cell, 72(3), 444-456 (2018)
Chao-Guo You et al.
Cancer medicine (2018-05-16)
FM19G11 is a small molecular agent that inhibits hypoxia-inducible factor-1-alpha (HIF-1α) and other signaling pathways. In this study, we characterized the modulating effects of FM19G11 on O6 -methylguanine DNA-methyltransferase (MGMT), the main regulator of temozolomide (TMZ) resistance in glioblastomas. This
Sung Ji Choi et al.
PloS one, 8(3), e58662-e58662 (2013-03-23)
Although both glucose deprivation and hypoxia have been reported to promote cascades of biological alterations that lead to induction of inflammatory mediators, we hypothesized that glucose deprivation and hypoxia might show neutral, synergistic or antagonistic effects to each other on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8807-5MG | 04061832632032 |
| F8807-25MG | 04061832632025 |