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F9786

Sigma-Aldrich

Fibroblast Growth Factor-Basic Heparin Stabilized human

FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture

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Synonym(s):
rhbFGF
CAS Number:
106096-93-9
MDL number:
MFCD00081382
NACRES:
NA.77

biological source

human

recombinant

expressed in E. coli

sterility

sterile-filtered

form

aqueous solution

potency

0.03-3.0 ng/mL ED50/EC50

quality

endotoxin tested

packaging

pkg of 1 and 5 mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P09038

storage temp.

2-8°C

Gene Information

human ... FGF2(2247)

Related Categories

General description

Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.

Application

Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.

Biochem/physiol Actions

Fibroblast growth factor 2 (FGF2) participates in tissue development and repair. It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system. FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor. bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types. In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion. It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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H Fukumoto et al.
Neuroscience letters, 122(2), 221-224 (1991-01-28)
Recombinant human basic fibroblast growth factor (rhbFGF) was found to induce secretion of nerve growth factor (NGF) in cultured astrocytes from rat brain. The induction was concentration dependent; a maximum increase of 2-fold was observed at concentrations of 3-10 ng/ml

Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast growth factors in cell culture and various growth factors for your research

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