G0500
D-(+)-Galactosamine hydrochloride
≥99% (HPLC)
Synonym(s):
2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
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Quality Level
assay
≥99% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
≤0.5% Glucosamine (HPAE)
color
white to off-white
mp
172-180 °C
solubility
H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
storage temp.
room temp
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
General description
D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.
Application
D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.
D-(+)-Galactosamine hydrochloride has been used:
- for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
- in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
- in mice for the generation of primary bone marrow-derived macrophages (BMDMs)
Biochem/physiol Actions
Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Xing Lin et al.
Biological & pharmaceutical bulletin, 37(4), 625-632 (2014-05-13)
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate
Yating Li et al.
Applied microbiology and biotechnology, 103(1), 375-393 (2018-10-23)
Acute liver failure is a drastic, unpredictable clinical syndrome with high mortality. Various preventive and adjuvant therapies based on modulating the gut flora have been proposed for hepatic injury. We aimed to explore the preventive and therapeutic effects of Bifidobacterium
Aoxiang Zhuge et al.
Applied microbiology and biotechnology, 104(17), 7437-7455 (2020-07-16)
Acute liver failure is a clinical emergency associated with high mortality. Accumulating evidence indicates that gut microbiota participates in the progression of liver injury, and preventive therapies based on altering gut microbiota are of great interest. Previous studies demonstrated that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G0500-25G | 04061833623718 |
| G0500-5G | 04061833623725 |
| G0500-10MG | 04061833623701 |