G1639
D-(+)-Galactosamine hydrochloride
BioReagent, suitable for cell culture
Synonym(s):
2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H13NO5 · HCl
CAS Number:
Molecular Weight:
215.63
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
NACRES:
NA.75
EC Number:
217-198-1
Beilstein/REAXYS Number:
3697825
biological source
fish cartilage (shark)
Quality Level
product line
BioReagent
assay
≥99%
technique(s)
cell culture | mammalian: suitable
impurities
Glucosamine, essentially free
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
Application
D-(+)-Galactosamine hydrochloride has been used to:
- induce livery injury
- inflammatory liver injury
- acute liver failure (ALF) in mice
Biochem/physiol Actions
Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
Huber Y, et al.
Cell Death & Disease, 8(6), e2893-e2893 (2017)
D-galactosamine lethality model: scope and limitations
Silverstein R
Journal of endotoxin research, 10(3), 147-162 (2004)
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G1639-1G | 04061833628300 |
| G1639-100MG | 04061833628294 |
| G1639-5G | 04061833628317 |