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I0160

Imipenem monohydrate

≥98% (HPLC), B-lactam antibiotic, powder

Synonym(s):

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate

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About This Item

Empirical Formula (Hill Notation):
C12H17N3O4S · H2O
CAS Number:
74431-23-5
Molecular Weight:
317.36
NACRES:
NA.77
PubChem Substance ID:
329815301
UNSPSC Code:
12352200
EC Number:
264-734-5
MDL number:
MFCD09753321
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Product Name

Imipenem monohydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

antibiotic activity spectrum

mycobacteria

mode of action

cell wall synthesis | interferes

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

−20°C

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

General description

Chemical structure: β-lactam

Application

Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.

Biochem/physiol Actions

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
Imipenem monohydrate is a broad spectrum B-lactam antibiotic.
Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
066M4743V
026M4730V
065M4739V
109K47204
109K47203

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Efficacy of imipenem/cilastatin in endocarditis
Dickinson G, et al.
The American Journal of Medicine, 78(6), 117-121 (1985)
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Garcia Salguero C, et al.
Antimicrobial Agents and Chemotherapy, AAC-00873 (2015)
Stefania Correale et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 9), 1697-1706 (2013-09-04)
The modelling of peptidoglycan is responsible for key cellular processes in Mycobacterium tuberculosis such as cell growth, division and resuscitation from dormancy. The structure of M. tuberculosis peptidoglycan is atypical since it contains a majority of 3,3 cross-links synthesized by L,D-transpeptidases
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Global Trade Item Number

SKUGTIN
I0160-25MG04061835304813
I0160-5MG04061835304820