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I2285

IPA-3

Name: IPA-3
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

1,1′-Disulfanediyldinaphthalen-2-ol

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₄O₂S₂

CAS Number:

42521-82-4

Molecular Weight:

350.45

NACRES:

NA.77

PubChem Substance ID:

329815364

UNSPSC Code:

12352200

MDL number:

MFCD00388917

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

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Properties

Quality Level

200

assay

≥95% (HPLC)

form

powder

color

off-white to yellow

solubility

DMSO: >20 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34

InChI

1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H

InChI key

RFAXLXKIAKIUDT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

IPA-3 is an allosteric inhibitor of Pak1.

IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.

pictograms

GHS05,GHS09

signalword

Danger

hcodes

H318,H410

pcodes

P273 - P280 - P305 + P351 + P338 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target.

Mathilde Gavillet et al.

American journal of hematology, 93(2), 269-276 (2017-11-11)

NET formation in mice (NETosis) is supported by reactive oxygen species (ROS) production by NADPH oxidase and histone hypercitrullination by peptidylarginine deiminase 4 (PAD4). Rac1 and Rac2, expressed in polymorphonuclear neutrophils (PMNs), regulate the cytoskeleton, cell shape, adhesion, and migration

Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture.

Florian Ingo Schmidt et al.

The EMBO journal, 30(17), 3647-3661 (2011-07-28)

Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and therefore require an unusual cellular entry mechanism. By a combination of fluorescence and electron microscopy

Estimating high-risk cannabis and opiate use in Ankara, Istanbul and Izmir.

Ludwig Kraus et al.

Drug and alcohol review, 36(5), 626-632 (2016-06-29)

Information on high-risk drug use in Turkey, particularly at the regional level, is lacking. The present analysis aims at estimating high-risk cannabis use (HRCU) and high-risk opiate use (HROU) in the cities of Ankara, Istanbul and Izmir. Capture-recapture and multiplier

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Global Trade Item Number

SKU	GTIN
I2285-25MG	04061833219171
I2285-5MG	04061833848388