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I2406

IL-11 human

Name: IL-11 human
Brand: SIGMA

>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-11 human, IL-11

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00212208

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf21 cells

Assay:

>97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

23 kDa

Impurities:

endotoxin, tested

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Properties

Product Name

Interleukin-11 human, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.06-0.24 ng/mL ED₅₀

mol wt

23 kDa

packaging

pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P20809

storage temp.

−20°C

Gene Information

human ... IL11(3589)

Description

General description

Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.

The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.

Biochem/physiol Actions

Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.

Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

Physical form

Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.

Analysis Note

The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

低风险生物材料

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Articles

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

Global Trade Item Number

SKU	GTIN
I2406-5UG	04061833848487