I4657
Insulin-like Growth Factor-I Receptor human
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
IGF-I Receptor
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About This Item
biological source
human
Quality Level
recombinant
expressed in NSO cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
α-chain ~120 & 150 kDa, β subunit ~46 & 50 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IGF1R(3480)
General description
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
Application
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
Biochem/physiol Actions
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
Physical form
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
Analysis Note
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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