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K2628

Ketotifen fumarate salt

≥99% (TLC), powder, H₁ histamine receptor antagonist

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About This Item

Empirical Formula (Hill Notation):
C19H19NOS · C4H4O4
CAS Number:
34580-14-8
Molecular Weight:
425.50
NACRES:
NA.77
PubChem Substance ID:
24278506
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
MFCD00079394
Form:
powder
Quality level:
100
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Product Name

Ketotifen fumarate salt,

form

powder

Quality Level

100

originator

Novartis

SMILES string

OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24

InChI

1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Gene Information

human ... HRH1(3269), PDE7B(27115)

General description

Ketotifen fumarate salt is an antihistamine drug.

Application

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Biochem/physiol Actions

Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.
H1 histamine receptor antagonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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