Skip to Content
Merck
CN

Key Documents

View All Documentation

L7795

Levocetirizine dihydrochloride

≥98% (HPLC)

Synonym(s):

Levocetirizine dihydrochloride, (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C21H25ClN2O3·2HCl
CAS Number:
130018-87-0
Molecular Weight:
461.81
NACRES:
NA.77
PubChem Substance ID:
329817657
UNSPSC Code:
12352200
MDL number:
MFCD07366507
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

H2O: ≥23 mg/mL

storage temp.

room temp

SMILES string

Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1

InChI key

PGLIUCLTXOYQMV-GHVWMZMZSA-N

Gene Information

human ... HRH1(3269)

General description

Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine. The response of levocetirizine to histamine is comparatively higher to cetirizine.

Application

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

Biochem/physiol Actions

Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine
Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Still not finding the right product?

Explore all of our products under Levocetirizine dihydrochloride

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
084M4706V
113M4732V
041M4733V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

组胺受体

我们提供多种与组胺受体相关的产品，以满足您的各类研究需求。

Histamine Receptors

We offers many products related to histamine receptors for your research needs.

A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects
Grant JA, et al.
Annals of Allergy, Asthma & Immunology, 88(2), 190-197 (2002)
Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study
Hulhoven R, et al.
European Journal of Pharmacology, 63(11), 1011-1017 (2007)
Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry
Eom HY, et al.
Journal of Pharmaceutical and Biomedical Analysis, 117, 380-389 (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
L7795-10MG04061833965702
L7795-50MG04061833965719