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L9668

Lidoflazine

Name: Lidoflazine
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₅F₂N₃O

CAS Number:

3416-26-0

Molecular Weight:

491.62

NACRES:

NA.77

PubChem Substance ID:

329817673

UNSPSC Code:

12352200

EC Number:

222-312-8

MDL number:

MFCD00057353

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChI key

ZBIAKUMOEKILTF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

HERG calcium channel blocker

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 μM

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

127K4606V

127K46061

127K4606

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Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack.

Thomas P Zonneveld et al.

The Cochrane database of systematic reviews, 7, CD007858-CD007858 (2018-07-20)

Stroke is an important cause of death and disability worldwide. Since high blood pressure is an important risk factor for stroke and stroke recurrence, drugs that lower blood pressure might play an important role in secondary stroke prevention. To investigate

Effects of lidoflazine on left ventricular function in patients.

S G De Hert et al.

Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)

The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function. Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner. A university hospital. The

Central-to-peripheral arterial pressure gradient during cardiopulmonary bypass: relation to pre- and intra-operative data and effects of vasoactive agents.