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L9793

LP44

Name: LP44
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₃₈ClN₃OS

CAS Number:

824958-12-5

Molecular Weight:

488.13

NACRES:

NA.77

PubChem Substance ID:

329817675

UNSPSC Code:

12352200

MDL number:

MFCD09971090

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: ≥2 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2

InChI

1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H

InChI key

DWGKCWWWKHCVDH-UHFFFAOYSA-N

Description

Application

LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.

Biochem/physiol Actions

LP44 is a high affinity 5-HT₇ receptor agonist.

LP44 is a high affinity 5-HT₇ receptor agonist. K_i = 0.22 nM. LP44 displays selectivity over 5-HT_1A and 5-HT_2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC₅₀ = 2.56 μM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Global Trade Item Number

SKU	GTIN
L9793-10MG	04061832072159
L9793-50MG	04061832072166