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M1254

Sigma-Aldrich

MOPS

≥99.5% (titration)

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Synonym(s):
3-(N-Morpholino)propanesulfonic acid, 4-Morpholinepropanesulfonic acid
Empirical Formula (Hill Notation):
C7H15NO4S
CAS Number:
1132-61-2
Molecular Weight:
209.26
Beilstein:
1106776
EC Number:
214-478-5
MDL number:
MFCD00006183
PubChem Substance ID:
24896628
NACRES:
NA.25

Quality Level

200

Assay

≥99.5% (titration)

form

crystalline powder

technique(s)

electrophoresis: suitable

pH

2.5-4 (25 °C, 209 g/L)

useful pH range

6.5-7.9

pKa (25 °C)

7.2

solubility

water: 0.5 g/mL, clear, colorless

λ

33 % in H2O

application(s)

diagnostic assay manufacturing

storage temp.

room temp

SMILES string

OS(=O)(=O)CCCN1CCOCC1

InChI

1S/C7H15NO4S/c9-13(10,11)7-1-2-8-3-5-12-6-4-8/h1-7H2,(H,9,10,11)

InChI key

DVLFYONBTKHTER-UHFFFAOYSA-N

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General description

3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.

Application

MOPS has been used as:
  • a cell culture additive component in lentiviral particle production
  • as a buffering agent in microbial growth medium and nuclei extraction buffer

Other Notes

Easily compare specifications for MOPS products with the MOPS specification table.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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(Un) suitability of the use of pH buffers in biological, biochemical and environmental studies and their interaction with metal ions-a review
Ferreira CMH, et al.
Royal Society of Chemistry Advances, 5(39), 30989-31003 (2015)
Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles
Mitta B, et al.
Metabolic engineering, 7(5-6), 426-436 (2005)
Survival to different acid challenges and outer membrane protein profiles of pathogenic Escherichia coli strains isolated from pozol, a Mexican typical maize fermented food
Sainz T, et al.
International Journal of Food Microbiology, 105(3), 357-367 (2005)
Interactions of biological buffers with macromolecules: The ubiquitous ?smart? polymer PNIPAM and the biological buffers MES, MOPS, and MOPSO
Taha M, et al.
Macromolecules, 44(21), 8575-8589 (2011)
PROTOCOLS: Chromatin immunoprecipitation from Arabidopsis tissues
Yamaguchi N, et al.
The Arabidopsis Book / American Society of Plant Biologists, 12(3), e170-e170 (2014)
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