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N3136

Naltrexone hydrochloride

Name: Naltrexone hydrochloride
Brand: SIGMA

≥99% (HPLC), powder, opioid receptor antagonist

Synonym(s):

Naltrexone HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₃NO₄ · HCl

CAS Number:

16676-29-2

Molecular Weight:

377.86

NACRES:

NA.77

PubChem Substance ID:

24278051

UNSPSC Code:

12352200

EC Number:

240-723-0

MDL number:

MFCD00069324

Beilstein/REAXYS Number:

3580333

Form:

powder

Quality level:

100

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Properties

Product Name

Naltrexone hydrochloride,

form

powder

Quality Level

100

originator

Novartis

storage temp.

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6

InChI

1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

InChI key

RHBRMCOKKKZVRY-ITLPAZOVSA-N

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Description

Application

Naltrexone hydrochloride has been used:

as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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