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O1257

Oleic Acid-Water Soluble

Name: Oleic Acid-Water Soluble
Brand: SIGMA

powder, BioReagent, suitable for cell culture

Synonym(s):

Oleic Acid–Cyclodextrin Complex

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About This Item

NACRES:

NA.75

PubChem Substance ID:

24897936

UNSPSC Code:

12352211

MDL number:

MFCD00064242

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Properties

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

form

powder

composition

Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)

technique(s)

cell culture | mammalian: suitable

solubility

H₂O: 50 mg/mL, clear to slightly hazy

storage temp.

−20°C

SMILES string

CCCCCCCC\C=C/CCCCCCCC(O)=O

InChI

1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-

InChI key

ZQPPMHVWECSIRJ-KTKRTIGZSA-N

Gene Information

human ... SOAT1(6646), SOAT2(8435)

Description

Application

Oleic Acid-Water Soluble has been used:

to prepare the FFAs (free fatty acids) mixture for cell treatment
to investigate its effect on the solute carrier family 2 member 4 (SLC2A4)/GLUT4 expression in L6 muscle cells and as potential transcriptional regulators
in the preparation of fatting media for the induction of in vitro steatosis in primary human hepatocytes

Other Notes

Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Articles

油酸在细胞培养中的应用

不饱和脂肪酸、油酸和其他细胞培养成分如何影响无血清、无蛋白细胞培养系统（用于生物制造包括单克隆抗体在内的异源蛋白）的性能。

Oleic Acid in Cell Culture

How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

Stearic Acid in Cell Culture

Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.

A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis

Ai L, et al.

International Journal of Biological Sciences, 11(12), 1436-1436 (2015)

Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.

Takashi Okumura et al.

Oncotarget, 8(11), 18280-18295 (2017-04-15)

Pancreatic cancer progression involves components of the tumor microenvironment, including stellate cells, immune cells, endothelial cells, and the extracellular matrix. Although peripancreatic fat is the main stromal component involved in extra-pancreatic invasion, its roles in local invasion and metastasis of

Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells

Poletto A C, et al.

Molecular and Cellular Endocrinology, 401(12), 65-72 (2015)

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Global Trade Item Number

SKU	GTIN
O1257-10MG	04061834213161