O9387
Oxatomide
≥99%
Synonym(s):
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
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About This Item
Empirical Formula (Hill Notation):
C27H30N4O
CAS Number:
Molecular Weight:
426.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
262-320-9
MDL number:
Quality Level
assay
≥99%
form
powder
color
white
solubility
DMSO: soluble, ethanol: soluble
originator
Johnson & Johnson
SMILES string
O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
InChI
1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI key
BAINIUMDFURPJM-UHFFFAOYSA-N
Gene Information
human ... DRD3(1814)
General description
Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.
Biochem/physiol Actions
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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