P118
Phaclofen
solid
Synonym(s):
3-Amino-2-(4-chlorophenyl)propanephosphonic acid
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About This Item
Empirical Formula (Hill Notation):
C9H13ClNO3P
CAS Number:
Molecular Weight:
249.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
solid
Quality Level
impurities
≥97% (NMR)
color
white
solubility
0.1 M HCl: 13.3 mg/mL, methanol: 19.3 mg/mL, DMSO: insoluble
SMILES string
NCC(CP(O)(O)=O)c1ccc(Cl)cc1
InChI
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChI key
VSGNGLJPOGUDON-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
General description
Phaclofen is a phosphonic acid derivative of baclofen.
Application
Phaclofen has been used to block GABAB receptor.
Biochem/physiol Actions
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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