P1645
Palmitoyl-L-carnitine chloride
≥98% (TLC), powder
Synonym(s):
O-Palmitoyl-L-carnitine chloride
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About This Item
Linear Formula:
C23H46NO4 · Cl
CAS Number:
Molecular Weight:
436.07
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
242-642-6
Beilstein/REAXYS Number:
4071005
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
color
white
solubility
H2O: 25 mg/mL (with heat or sonication)
lipid type
saturated FAs
storage temp.
−20°C
SMILES string
[Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
InChI
1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
InChI key
GAMKNLFIHBMGQT-ZMBIFBSDSA-N
Application
Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).
Biochem/physiol Actions
Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine.
Q Y Liu et al.
Biochemical and biophysical research communications, 228(2), 252-258 (1996-11-12)
We have studied the effect of a palmitoyl-L-carnitine (L-PC) on single cardiac L-type Ca channels incorporated from porcine ventricular sarcolemma into planar lipid bilayers where we could control the concentration, intracellular and/or extracellular location, and duration of L-PC treatment. We
S R Stapleton et al.
British journal of pharmacology, 107(4), 1192-1197 (1992-12-01)
1. The effects of palmitoyl-DL-carnitine (0.01 to 1 mM) on whole cell voltage-activated calcium channel currents carried by calcium or barium and Ca(2+)-activated chloride currents were studied in cultured neurones from rat dorsal root ganglia. 2. Palmitoyl-DL-carnitine applied to the
Sriram Devanathan et al.
Biology of sex differences, 7, 25-25 (2016-05-18)
Cardiovascular disease is the leading cause of death among diabetic patients. Importantly, recent data highlight the apparent sexual dimorphism in the pathogenesis of cardiovascular disease in diabetics with respect to both frequency- and age-related risk factors. The disposition to cardiovascular
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P1645-10MG | 04061834356028 |
| P1645-25MG | 04061832865010 |
| P1645-5MG | 04061832865027 |