PRS3331
Anti-XIAP antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-X-linked inhibitor of apoptosis
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
9
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 55 kDa
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XIAP(331)
General description
XIAP (X-linked inhibitor of apoptosis protein) belongs to the inhibitor of apoptosis (IAP) family. It is located on chromosome Xq25.
Immunogen
a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
Application
Anti-XIAP has been used in immunohistochemistry {16,17}.
Biochem/physiol Actions
XIAP (X-linked inhibitor of apoptosis protein) modulates several cellular processes like TGF-β (transforming growth factor β) signaling, NF-κB (nuclear factor-κB) pathway, autophagy and inflammatory responses. XIAP mutations are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3331.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress
Riley A, et al.
Nucleic Acids Research, 38(14), 4665-4674 (2010)
Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury
Reigada D, et al.
Neuroscience, 300, 404-417 (2015)
Chao Chen et al.
Oncology letters, 15(1), 821-832 (2018-02-07)
The X-linked inhibitor of apoptosis protein (XIAP) is the best characterized member of the IAP family and is a potent inhibitor of the caspase/apoptosis pathway. It has also been revealed that XIAP has additional biological functions that rely on its
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PRS3331-100UG | 04061832178738 |