R6527
Reboxetine mesylate hydrate
>96% (HPLC), noradrenaline uptake inhibitor, solid
Synonym(s):
(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra
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About This Item
Empirical Formula (Hill Notation):
C19H23NO3 · CH3SO3H · xH2O
CAS Number:
Molecular Weight:
409.50 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Reboxetine mesylate hydrate, >96% (HPLC), solid
Quality Level
assay
>96% (HPLC)
form
solid
storage condition
desiccated
color
white to tan
solubility
H2O: >5 mg/mL at ≤60 °C
shipped in
wet ice
storage temp.
2-8°C
SMILES string
O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3
InChI
1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
InChI key
SZPHEVAYLIVGRC-BAMQSBMESA-N
Application
Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
- to study its effects on the surge of dopamine in the cortex of mice brain
- to study its anti-immobility effects on the behavior of mice
- to analyze its effects on the probabilistic reversal learning task in rodents
Biochem/physiol Actions
Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
Reboxetine exhibits anti-depressant activity.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S Kasper et al.
Expert opinion on pharmacotherapy, 1(4), 771-782 (2001-03-16)
Several treatment approaches are available for treatment of depression. However, reboxetine is the first selective noradrenaline re-uptake inhibitor. Whereas formerly only noradrenaline re-uptake inhibitors with a mixed mechanism of action were available. These included action not only at noradrenergic, but
Charlotte J W Connell et al.
Medicine and science in sports and exercise, 49(9), 1778-1788 (2017-04-30)
Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the
Kristine Chobanyan-Jürgens et al.
Scientific reports, 8(1), 7748-7748 (2018-05-19)
Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved
Global Trade Item Number
| SKU | GTIN |
|---|---|
| R6527-25MG | 04061832093208 |
| R6527-5MG | 04061832084442 |